One of the compaines founded by Dr. Pawan Seth of Irvine, California is sponsoring a study to find a treatment for patients with advanced Peripheral Arterial Disease (PAD) and Critical Limb Ischemia (CLI).
This study seeks to determine if treatment with adult stem cells, taken from the patient’s own bone marrow, can improve healing and prevent amputation.
Peripheral Arterial Disease (PAD) is a condition which affects approximately 12 million Americans. It occurs when blood vessels become narrowed or locked by plaque, which decreases the blood flow to the area. PAD can develop in other areas of the body, but is commonly found in the legs, feet and toes. If left untreated, it can cause severe leg pain and lead to critical limb ischemia.
PAD can progress to Critical Limb Ischemia, which means there is not enough blood being delievered to the leg to keep the tissue alive. An estimated 1.5-2 million people in the United States suffer from CLI, and are at risk of amputation of the toes, feet, and legs.
One of Dr. Seth’s goals is to develop therapies for diseases such as peripheral arterial disease, osteoarthritis, neurodegenerative and coronary diseases that at this point are without effective drug or medical therapies. Once studies are complete, the successful therapies will be submitted for FDA approval to market these therapies. In addition, Dr. Pawan Seth of Irvine, CA will seek to provide these therapies to underdeveloped and developing nations through charitable foundations.
Dr. Seth is also a committe member of the Allen Diabetes Center Oversight Committee at Hoag Hosptial.